King Salman Heart Centre has three major domains:
- Adult Cardiology department that includes adult Coronary care unit, Percutaneous coronary diagnostic and intervention, Echocardiography, Advanced heart failure, and electrophysiology.
- Pediatric Cardiology department that includes: percutaneous pediatric cardiac intervention, Paediatric Echocardiography, Paediatric electrophysiology, Foetal heart, Paediatric cardiovascular imaging, Paediatric heart failure, and congenital heart disease.
- Cardiovascular and Thoracic surgery department includes; adult cardiac surgery, pediatric cardiac surgery, thoracic surgery, and vascular surgery.